ANTIBODY THAT CROSS-REACTS WITH KIR2DL1 AND KIR2DL2/3 GENE AND THE METHOD THEREOF

摘要

A method of producing an antibody which cross-reacts with multiple KIR2DL gene products and which neutralizes the inhibitory activity of such KIRs, said method comprising the steps of: (a) immunizing a non-human mammal with an immunogen comprising a KIR2DL polypeptide; (b) preparing antibodies from said immunized mammal, wherein said antibodies bind said KIR2DL polypeptide, (c) selecting antibodies of (b) that cross-react with at least two different KIR2DL gene products, and (d) selecting antibodies of (c) that potentiate NK cells (e) selecting an antibody that binds a primate NK cell or KIR polypeptide. Reference: Figure 1.