(a) to design a GC-C receptor peptide inhibitor suitable for oral administration.

摘要

Described in this Stable Solid formulations suitable for oral administration of linaclotide and Methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the Amino Acid Sequence Glu Tyr CYS CYS ASN Pro Ala CYS CYS THR Gly Tyr (linaclotide ") or one of its pharmaceutically acceptable Salts.Linaclotide formulations described herein are stable and have enough Life deposit to manufacture, store and distribute the drug.