TRANSDERMAL THERAPEUTIC SYSTEM FOR PARKINSON'S DISEASE THAT INDUCES HIGH LEVELS OF ROTIGOTINE IN PLASMA.

摘要

A silicone-based transdermal therapeutic system comprising a mixture of at least one high adhesion silicone contact adhesive and at least one of medium adhesion as the main adhesive components, which has an area of 10 to 40 cm 2 and containing 0.1 to 3.15 mg / cm 2 of free base rotigotine as an active ingredient, in which the silicone-based transdermal system is suitable for inducing an average plasma rotigotine concentration within the range of 0, 4 to 2 ng / ml 24 h after administration.