DIAGNOSIS AND TREATMENT OF INFECTIONS DUE TO STREPTOCOCCI AND ENTEROCOCCI

摘要

The present invention provides a purified bacterial protein expressed during infection due to streptococci or enterococci and isolatedfrom human sera, together with immunogenic fragments, analogs, inhibitors, antibodies and antigenic fragments specific thereto. Alsoprovided is a DNA sequence coding for a bacterial protein or an immunogenic fragment or an analogue thereof expressed during infectiondue to Streptococci or Enterococci, together with homologues thereof, together with vectors, probes and inhibitors therefor. Also providedis fibronectin or an immumogenic fragment thereof or an analogue thereof or an antibody thereto or an antigen binding fragment thereofwhen used in a method of treatment or diagnosis of the human or animal body for infection due to Streptococci or Enterococci. Alsoprovided are antibodies specific to HSP 90 or immunogenic fragments or analogues thereof for use in a method of diagnosis or treatmentof the human or animal body of infection due to streptococci or enterococci due to any one of the group of S.oralis, S.gordonii, S.sangais.