GENE THERAPY FOR HEMATOPOIETIC TUMOR BY PROLIFERATION-REGULATED VIRUS VECTOR CARRYING SURVIVIN PROMOTER

摘要

PROBLEM TO BE SOLVED: To provide a novel dosage form of a proliferation-regulated virus vector which enables the gene therapy for hematopoietic tumor using the vector and a novel therapy means for hematopoietic tumor using the dosage form.SOLUTION: A therapeutic agent for hematopoietic tumor comprises a proliferation-regulated virus vector carrying a nucleic acid that encodes at least one protein necessary for the replication of viruses and is under the regulation of a promoter for a gene capable of being expressed specifically in a hematopoietic tumor cell (preferably a survivin gene), and is characterized by being administered systemically in such a form that a hematopoietic tumor cell is infected by the vector.