How to detect the chemical group of light sensors, and analyte for use with visible light laser excitation beam and Raman spectroscopic detector

摘要

In order to detect the presence of chemical groups in an analyte 80 in a given sensor, an optical sensor and method for use with Raman spectroscopy detector and visible light laser excitation beam 60 is disclosed. The sensor, plasmon resonance mirror 20 which is formed on the sensor surface substrate 10, the substrate 10, the plasmon resonance particle layer 40, and about 2~40nm thickness separating the particle layer 40 and the mirror 20 arranged on the mirror 20 on a transparent dielectric layer 30 is included optically. Coating to bind the i analyte molecules 80, particle size and shape substantially uniform in the range between ii50~200nm, and the particle layer 40, spacing between particles smaller than the wavelength of iii laser excitation beam and a periodic array of plasmon resonance particles having. The ^device can detect the analyte molecules 80 in a single amplification factor of up to 10 12 ^1014.