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Dose-controlled transdermal promethazine compositions and methods of use
Dose-controlled transdermal promethazine compositions and methods of use
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机译:剂量控制的透皮异丙嗪组合物和使用方法
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摘要
The current invention provides formulations for transdermal delivery of promethazine which achieve delivery of the drug with consistent plasma levels. The topical formulations of the invention are superior to both rectal suppositories and oral dosage forms in that variable blood levels, first-pass metabolism, unpredictable peaks in blood levels, and variable bioavailability are minimized. Formulations of the invention provide antiemetic and antipruritic relief to patients in need of treatment while minimizing side effects and adverse reactions known to occur with other routes of administration and other formulations.
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