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Methods and means for controlling the endocytosis and subsequent degradation of growth hormone receptor
Methods and means for controlling the endocytosis and subsequent degradation of growth hormone receptor
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机译:控制生长激素受体的内吞作用和随后降解的方法和手段
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摘要
The invention relates to the field of regulating metabolic processes, for example, to regulate the presence and/or activity of a receptor at the surface of a cell. The invention provides a method for controlling the presence of a receptor at the surface of a cell comprising interfering with the interaction of an F-box protein with a ubiquitin/proteasome binding site of the receptor, wherein the ubiquitin/proteasome binding site comprises particular amino acid sequences. The invention further provides a method for controlling the presence of a growth hormone receptor (GHR) at the surface of a cell comprising interfering with the interaction of an F-box protein with a ubiquitin/proteasome binding site of the GHR.
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