MICRONEEDLE ARRAY USING POROUS SUBSTRATE AND PRODUCTION METHOD THEREOF

摘要

In order to produce a microneedle array which includes a macromolecular drug such as a vaccine antigen and insulin at its acral portion using a water-soluble thread-forming polymer for a base, there is a need for a substrate which enables a solvent to be efficiently removed so that a base dense solution containing a target substance can be dried and cured while still inserted in a mold. This problem is resolved by using a porous water-insoluble substrate or a porous filter as a substrate, which allows drying and curing as well as peeling from a female mold to be carried out while the base dense solution containing a target substance is still filled in the mold.