首页>
外国专利>
Quinaldine based semisquaraines and squaraine dyes, process for preparation thereof and use thereof
Quinaldine based semisquaraines and squaraine dyes, process for preparation thereof and use thereof
展开▼
机译:喹诺丁类半方酸和方酸类染料,其制备方法及其用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides quinaldine-based semisquaraines, symmetrical and unsymmetrical squaraine dyes represented by the general formulae 1, 2 and 3 and/or pharmaceutically acceptable derivatives thereof as sensitizers for photodynamic therapeutical and industrial applications. These symmetrical and unsymmetrical squaraine dyes posses absorption which extends well into the photodynamic window (650-800 nm) and hence are useful for the treatment of deep seated tumors. The absorption of these dyes can be tuned by changing the substituents on the quinaldine moiety thereby enabling the development of a library of dyes which have absorption ranging from 650 to 800 nm. They also exhibited fluorescence emission in the long wavelength region making them useful as near infrared fluorescence sensors for the detection of tumors. These dyes are non-toxic in the dark and exhibit good photocytotoxicity. Accordingly the quinaldine based semisquaraines, symmetrical and unsymmetrical squaraines are extremely useful as diagnostic and therapeutic agents for photodynamic therapeutical and industrial applications.
展开▼