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Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids

机译：吗啡和托烷生物碱的一锅法 N -去甲基化/ N -酰化方法

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摘要

The present invention provides a method for the N-demethylation and/or N-acylation of an N-methylated heterocycle such as morphine alkaloids or tropane alkaloids. The method comprises reacting the heterocycle with an acylating agent in the presence of a metal catalyst. 展开▼

机译：本发明提供了用于N-甲基化杂环如吗啡生物碱或托烷生物碱的N-脱甲基化和/或N-酰化的方法。该方法包括在金属催化剂的存在下使杂环与酰化剂反应。展开▼

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公开/公告号US7999104B2

专利类型

公开/公告日2011-08-16

原文格式PDF

申请/专利权人 ROBERT JAMES CARROLL;HANNES LEISCH;TOMAS HUDLICKY;D. PHILLIP COX;
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申请/专利号US20070771191

发明设计人 ROBERT JAMES CARROLL;HANNES LEISCH;TOMAS HUDLICKY;D. PHILLIP COX;
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申请日2007-06-29

分类号C07D489/02;C07D489;

国家 US

入库时间 2022-08-21 18:11:55

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1. 用于吗啡生物碱和托烷生物碱的N-脱甲基化/N-酰化的一锅法 [P] . 中国专利： CN101801978B . 2013.11.06

2. 用于吗啡生物碱和托烷生物碱的N-脱甲基化/N-酰化的一锅法 [P] . 中国专利： CN101801978A . 2010-08-11

3. METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS [P] . IN268093B . 2015-08-21

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4. Methods for one-pot n-demethylation/n-acylation of morphine and tropane alkaloids [P] . IL202993A . 2014-11-30

机译：吗啡和托烷生物碱的一锅正脱甲基/正酰化方法

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