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METHODS FOR PREDICTING RESPONSIVENESS OF A DISEASE OR DISORDER TO A RECEPTOR TYROSINE KINASE INHIBITOR BY ANALYSIS OF MUTATIONS IN PIK3CA
METHODS FOR PREDICTING RESPONSIVENESS OF A DISEASE OR DISORDER TO A RECEPTOR TYROSINE KINASE INHIBITOR BY ANALYSIS OF MUTATIONS IN PIK3CA
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机译:通过突变分析分析预测酪氨酸激酶抑制剂对疾病或疾病反应的方法
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摘要
The present disclosure relates generally to methods and materials for determining the responsiveness of a subject with a disease or disorder to an inhibitor of a receptor tyrosine kinase including, for example, IGF1R. Such methods may comprise obtaining a biological sample from the subject, assaying the biological sample for one or more PIK3CA mutations, determining if one or more PIK3CA mutations are present in the biological sample, and employing the determination of one or more PIK3CA mutations in the biological sample to predict responsiveness of the subject to the receptor tyrosine kinase inhibitor.
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