The present invention relates to fusion peptides which exhibit potent anti-retroviral activity. The fusion peptides of the invention comprise a macromolecular carrier group fused to a gp41-derived DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LA1 gp41 protein, or fragments, analogs or homologs of DP178. The invention further relates to the uses of such fusion peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
展开▼
机译:本发明涉及表现出有效的抗逆转录病毒活性的融合肽。本发明的融合肽包含与gp41衍生的DP178(SEQ ID NO:1)肽融合的大分子载体基团,其对应于HIV-1 LA1 Sub> gp41蛋白的氨基酸638至673,或DP178的片段,类似物或同源物。本发明还涉及这种融合肽作为抑制人和非人逆转录病毒,特别是HIV向未感染细胞的传播的用途。
展开▼