2-aminobenzamide derivative c07d 307/14 c07d 307/22 c07d 309/14 c07d 319/12 c07d 401/12 c07d 405/12 c07d 413/12 c07d 417/12

摘要

2-AMINOBENZAMIDE DERIVATIVE. A new and excellent therapeutic or prophylactic agent is published for nociceptive pain, neuropathic pain, cancer pain, headache, bladder dysfunction or similar, which uses a preventive activity on the activation of the VR1 receptor. capsaicin. A benzamide derivative having a benzene ring fused to a monocyclic ring on a nitrogen atom in the amide group and an amino group replaced by a lower alkylamino or cyclic group in a position adjacent to the amide group is found to have a potent preventive activity about the activation of VR1 and an excellent pharmacological activity that uses preventive activity, and therefore the derivative can be used as a good therapeutic or prophylactic agent for a VR1-related disease, such as nociceptive pain, neuropathic pain, cancer pain, headache and bladder dysfunction.