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NEW DOUBLE ACTION RECEIVERS (DARA) ANTAGONISTS FOR AT1 ETA RECEPTORS

机译:适用于AT1 ETA接收器的新型双重作用受体(DARA)拮抗剂

摘要

NEW DOUBLE ACTION RECEPTOR ANTAGONISTS (DARA) FOR ATi AND ETA RECEPTORS The present invention relates to new compounds of the formula: where R1, R2, R3 and R31 are as specified here. The invention also refers to a method for preparing them, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the compounds and combinations mentioned above for the preparation of a medicament for the treatment of hypertension of different types, relief of damage to organs of different types, treatment or prevention of diabetic nephropathy, treatment of endothelin-mediated disorders and angiotensin, and treatment of prostate cancer.
机译:Ati和Eta受体的新型双作用受体拮抗剂(DARA)本发明涉及下式的新化合物:其中R1,R2,R3和R31如本文所述。本发明还涉及制备它们的方法,以及新化合物与先前已知试剂的组合。本发明还涉及上述化合物和组合在制备用于治疗不同类型的高血压,减轻不同类型的器官的损伤,治疗或预防糖尿病性肾病,治疗内皮素介导的药物中的用途。疾病和血管紧张素,以及前列腺癌的治疗。

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