Oxo Derivatives of 1 - 1, 2 - dihydro - isoqinolina, processes for their Preparation and Pharmaceutical compositions containing them

摘要

1. A compound of formula (I): where: R1 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C6) alkynyl, (CH2) aX-Ar and (CR101R102) aX-Ar, wherein said (C1-C6) alkyl is optionally substituted with 1, 2 or 3 groups independently selected from - (C1-C6) alkoxy, -halo, -OH, -heterocycloalkyl, (C3-C7) cycloalkyl and - NR8R9; R2 and R3 are independently selected from H, halo, (C1-C6) alkyl, (C1-C6) alkoxy and (CH2) dY; wherein said (C1-C6) alkyl is optionally substituted with 1, 2 or 3 groups independently selected from - (C1-C6) alkoxy, -halo and -OH; and where said (C1-C6) alkoxy is optionally substituted with 1,2 or 3 groups independently selected from -halo and -OH; and provided that when R2 is (CH2) d-Y, R3 is selected from H, halo, (C1-C6) alkyl and (C1-C6) alkoxy; and provided that when R3 is (CH2) d-Y, R2 is selected from H, halo, (C1-C6) alkyl and (C1-C6) alkoxy; R4 and R5 are independently selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, halo, CF3 and CN; R16 is selected from H, (C1-C6) alkyl and heterocycloalkyl, wherein said (C1-C6) alkyl is optionally substituted with - (C1-C6) alkoxy, -OH, -halo, - (C3-C7) cycloalkyl and - NR25R26; R17 is selected from H and (C1-C6) alkyl;or R16 and R17 together with the nitrogen atom to which they are attached form a 3 to 7 member ring, optionally containing another heteroatom selected from NR27, S and O; and optionally containing, when possible, 1 or 2 double bonds; wherein said ring is optionally substituted on carbon with 1 or 2 substituents independently selected from - (C1-C6) alkyl, (C1-C6) alkoxy, (C2-C6) alkenyl, -OH, -CN, halo and -NR25R26, wherein said - (C1-C6) alkyl is optionally substituted with -OH. R25 and R26 are independently selected from H and (C1-C6) alkyl wherein said (C1-C6) alkyl is optionally substituted with - (C1-C6) alkoxy, -OH, -halo,-(C3-C7) cyclopentanediol and - nr22r23; or R25 and R26, together with the nitrogen atoms attached to them, form a ring of 3 to 7 members, optionally containing another heteromorphic atom selected from among Nr24, s and O;