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IMPROVED BIOCATALYSTS FOR MANUFACTURING DULOXETINE ALCOHOL
IMPROVED BIOCATALYSTS FOR MANUFACTURING DULOXETINE ALCOHOL
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机译:用于制造度洛西汀醇的改进型生物催化剂
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摘要
The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.
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