RECOMBINANT NEWCASTLE DISEASE VIRUS COMPRISING A TRANSGENE ENCODING A FUSION PROTEIN COMPRISING A BINDING DOMAIN AND A HETEROLOGOUS DOMAIN COMPRISING A TOXIN

摘要

Disclosed is a recombinant oncolytic paramyxovirus comprising a nucleic acid with at least one transgene, wherein the transgene encodes a binding protein that has a therapeutic activity when expressed by a virus infected tumor cell, and wherein the binding protein is an fusion protein comprising at least binding domain and a geterologous domain containing a toxin.