Combination of DL4 chemicals and anticompetitive agents and their application in CCER treatment

摘要

The Invention provides methods for treating various types of cancer / tumor, Administering the combination of dii4 antagonists, in particular dii4 Antibodies and Fragments thereof that specifically bind to Human dii4 and chemotherapeutic agents. Combination Therapies of this type exhibited Synergistic effects compared to treatment with either Agent alone.Thus, the methods of the invention are particularly beneficial for cancer patients who have a low tolerance to Side Effects caused by high doses required for treatment by either Agent alone, being capable of reducing effective dosages Ace.Also provided are Pharmaceutical compositions and Kits containing dii4 antagonist and chemotherapeutic agents.