Use of compound n-phenyl-N '- (3-methyl-2-butenyl) thiourea to prepare medicaments for the treatment of hepatic encephalopathy.

摘要

Use of the compound N -phenyl- N '- (3-methyl-2-butenyl) thiourea for the preparation of medicaments for the treatment of hepatic encephalopathy.; The present invention relates to a pharmaceutical composition comprising the compound N -phenyl- N '- (3-methyl-2-butenyl) thiourea and the use of the compound N -phenyl- N' - (3-methyl-2-butenyl ) thiourea and said pharmaceutical composition in the manufacture of medicaments for the treatment of diseases associated with hyperammonemia, such as, but not limited thereto, generally hepatic encephalopathy or hepatic encephalopathy caused by cirrhosis in particular. This compound is capable of partially inhibiting the enzymatic activity of intestinal glutaminase activated phosphate (GAP), causing a reduction in ammonia production.