PURIFIED COMPOSITIONS OF 10-PROPARGYL-10-DEAZAAMINOPTERIN AND METHODS OF USING SAME IN THE TREATMENT OF TUMORS

摘要

Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacyagainst human tumors are shown to be far superior to methotrexate ("MTX") and are even superior to the newer clinical candidate edatrexate("EDX"). Moreover, 10-propragyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growthseveral weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat humantumors, particularly human mammary tumors and human lung cancer.