STABLE ARTESUNATE-AMODIAQUINE HYDROCHLORIDE COMPLEX TABLET AND PREPARATION METHOD THEREOF

摘要

The present invention provides an artesunate-amodiaquine hydrochloride complex tablet consisting of (parts by weight) artesunate (100), amodiaquine hydrochloride (352-353), pH regulator (45-55), filler (75-180), binder (5-35), disintegrant (70-80), glidant (3-13), and lubricant (5.7-10.7). The complex tablet is prepared by preparing artesunate and amodiaquine hydrochloride respectively into granules, and pressing into tablets. Artesunate is prepared into granules by using isopropanol as solvent. Calcium carbonate is used as a pH regulator in the complex tablet. The artesunate-amodiaquine hydrochloride complex tablet of the present invention has good stability, and is easy to produce and suitable for industrial production.