首页>
外国专利>
Methods and sequences to preferentially suppress expression of mutated huntingtin gene.
Methods and sequences to preferentially suppress expression of mutated huntingtin gene.
展开▼
机译:优先抑制突变的亨廷顿蛋白基因表达的方法和序列。
展开▼
页面导航
摘要
著录项
相似文献
摘要
Disclosed herein are methods and sequences to preferentially suppress the expression of the mutated huntingtin ("htt") protein over expression of the normal htt protein. Also disclosed are methods comprising screening an individual for the heterozygous presence of one or more single nucleotide polymorphisms within the individual's Huntington's genes; administering nucleic acid molecules comprising nucleotide sequences that preferentially suppress the expression of amino acid sequences encoding for mutated huntingtin ("htt") over suppressing the expression of amino acid sequences encoding for normal htt by targeting an area of a Huntington's disease gene that is heterozygous for the presence of one or more single nucleotide polymorphisms.
展开▼