Compositions and devices for reducing the mineral content of vascular calcified lesions

摘要

The present invention relates to reducing the mineral content of a vascular calcified lesion (14), i.e. a calcified lesion (14) present on the vascular tissue (12) of a host. The local environment of the lesion (14) is maintained at a pH below 4.0 for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion (14) with one or more acidic dissolution fluids. The acidic dissolution fluid(s) may be hypertonic and or may be hydrochloride solution or carbonic acid solution. The acidic dissolution fluid(s) may contain an oxygenating medium.