METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF 4-OXO-3,4-DIHYDRO-IMIDAZO5,1-D1,2,3,5TETRAZINES

摘要

The present invention provides a compound of general formula (II), or a salt or solvate thereof wherein A is independently -A¹, -A², -A³, -A⁴, -A⁵, -A⁶, or -A⁷, wherein: -A¹ is independently C_5-12heteroaryl, and is optionally substituted; -A² is independently thioamido or substituted thioamido; -A³ is independently imidamido, substituted imidamido, N-hydroxyimidamido, or substituted N-hydroxyimidamido; -A⁴ is independently hydroxamic acid or hydroxamate; -A⁵ is independently carboxamide or substituted carboxamide; -A⁶ is independently aliphatic C_2-6alkenyl, and is optionally substituted; and -A⁷ is independently carboxy or C_1-4alkyl-carboxylate; and its use in the synthesis of temozolomide and analogues thereof.