PROTEOMICS BIOMARKER FOR DETECTING THE EXPOSURE BY PHTHALATES

摘要

PURPOSE: A proteomics biomarker for detecting the exposure of phthalates is provided to quantitatively detect the exposure of phthalate in vivo and to prevent or treat diseases caused by phthalates. ;CONSTITUTION: A proteomics biomarker for detecting phthalate exposure contains ETFB(Isoform 1 of electron transfer flavoprotein subunit beta) or ITIH-2(Inter-alpha-trypsin inhibitor heavy chain H2). The phthalate is a compound of chemical formula 1. The compound of chemical formula 1 is benzyl butyl phthalate. A protein array for confirming phthalate exposure contains the proteomics biomarker. The biomarker is labeled with isotope, Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate), or rhodamine.;COPYRIGHT KIPO 2011