APPLICATION OF SUBSTITUTED DERIVATIVES OF PYRANONIC ACID FOR TREATMENT OF A METABOLIC SYNDROME

摘要

1. The use of compounds of formula I! ! wherein ! R1 is H, F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, NH2, NH (C1-C6) -alkyl, N ((C1-C6) -alkyl) 2, SF5, SO2- CH3, COOH, COO- (C1-C6) -alkyl, CONH2, (C1-C20) -alkyl, (C3-C20) -cycloalkyl, (C2-C20) alkenyl, (C2-C20) alkynyl, aryl, heterocyclyl, moreover, in the residues of (C1-C20) -alkyl and (C2-C20) -alkenyl, one or more individual —CH2 or —CH groups can be replaced by —O— and wherein alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heterocyclyl can be mono- or polysubstituted (by the following radicals):! F, Cl, Br, I, CF3, NO2, N3, CN, = O, COOH, COO- (C1-C6) -alkyl, CONH2, СО (NH (C1-C6) alkyl, CON [(C1-C6) alkyl] 2, cycloalkyl, (C1-C10) -alkyl, (C2-C6) alkenyl, (C2-C6) -alkynyl, O- (C1-C6) -alkyl, O-CO- (C1-C6) - alkyl, O-CO- (C1-C6) aryl, O-CO- (C1-C6) heterocyclyl; PO3H2, P (O) (Oalkyl) 2, (C1-C6) -alkylene-P (O) ( Alkyl) 2, O-P (O) (OH) 2, O-P (O) (O-alkyl) 2, SO3H, SO2-NH2, SO2NH (C1-C6) -alkyl, SO2N [(C1-C6) -alkyl ] 2, S- (C1-C6) -alkyl, S- (CH2) n-aryl, S- (CH2) n-heterocyclyl, SO- (C1-C6) alkyl, SO- (CH2) n-aryl, SO - (CH2) n-heterocyclyl, SO2- (C1-C6) -alkyl, SO2- (CH2) n-aryl, SO2- (CH2) n-heterocyclyl, SO2-NH (CH2) n-aryl, SO2-NH ( CH2) n-heterocyclyl, SO2-N ((C1-C6) -alkyl) (CH2) n-aryl, SO2-N (C1-C6) -alkyl) (CH2) n-heterocyclyl, SO2-N ((CH2) n-aryl) 2, SO2-N ((CH2) n- (heterocyclyl) 2, moreover, n can be = 0-6 and the aryl residue or heterocyclic residue can be substituted up to two times (by the following radicals): F, Cl, Br, OH, CF3, SF5, NO2, CN, OCF3, O- (C1-C6) -alkyl, (C1-C6) -alkyl, NH2; C (NH) (NH2), NH2, NH- (C1-C6) -alkyl, N ((C1-C6) -alkyl) 2, NH (C1-C7 ) -acyl, NH-CO- (C1-C6) -alkyl, NH-COO- (C1-C6) -alkyl, NH-CO-aryl, NH-CO-heterocyclyl, NH-COO-aryl, NH-COO- heterocyclyl, NH-CO-NH- (C1-C6) -alkyl), NH-CO-NH-aryl, NH-CO-NH-heterocyclyl, N [(C1-C6) -alkyl] -CO- (C1-C6 ) -alkyl, N [(C1-C6) alkyl] -COO- (C1-C6) -alkyl, N [(C1-C6-alkyl] -CO-aryl, N [(C1-C6) -alkyl] -CO -heterocyclyl, N [(C1-C6) -alkyl] -COO-aryl, N [(C1-C6) -alkyl] -COO-heterocyclyl, N [(C1-C6) -alkyl] -CO-NH- (C1 -C6) -alkyl), N [(C1-C6) -alkyl] -CO-NH-aryl, N [(C1- C6) -alkyl] -CO-NH-heterocyclyl, N [(C1-C6) -alkyl] -CO-N ((C1-C6) -alkyl) 2, N [(C1-C6) -alkyl] -CO- N ((C1-C6) -alkyl