SOLID FORMS CONTAINING (-) - O-DESMETHYLVENLAFXIN, AND THEIR APPLICATIONS

摘要

1. The crystalline form of the hydrochloride salt of a stereomerically pure compound of formula (I):! ! 2. The crystalline form of the stereomerically pure hydrochloride salt of (-) - O-desmethylvenlafaxine. ! 3. The crystalline form of the stereomerically pure hydrochloride salt of (-) - 1- [2- (dimethylamino) -1- (4-hydroxyphenyl) ethyl] cyclohexanol. ! 4. The crystalline form according to claim 1, 2 or 3, which contains water. ! 5. The crystalline form according to claim 4, which is a form A.! 6. The crystalline form according to claim 5, in which the molar ratio of water to hydrochloride salt of (-) - O-desmethylvenlafaxine is approximately one to one. ! 7. The crystalline form according to claim 5, in which water is present in an amount of from about 4 to about 8% of the total weight of the sample. ! 8. The crystalline form according to claim 4, which is characterized by mass loss during thermal gravimetric analysis from about 4 to about 8% of the total mass of the sample when heated from about 25 to about 110 ° C. ! 9. The crystalline form according to claim 4, which is characterized by an endothermic effect in differential scanning calorimetry with a temperature of the onset of the effect from about 50 to about 125 ° C. ! 10. The crystalline form according to claim 4, which has a dehydration temperature of from about 50 to about 125 ° C. ! 11. The crystalline form according to claim 4, which has a peak powder x-ray at a position of approximately 21.35 ° 2θ. ! 12. The crystalline form according to claim 11, which has peaks of an X-ray powder diffraction pattern at positions of about 14.48, 19.05, and 22.96 ° 2θ. ! 13. The crystalline form according to claim 5, which is obtained by crystallization of the hydrochloride salt of the compounds of formula (I) from water or a mixture of solvents containing water. ! 14. The crystalline form according to claim 4, which