A method for identifying cells exhibiting susceptible to modulation TRANSMISSION receptor-mediated fibroblast growth factor or its variants

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to field of biochemistry. Method of identifying cells, which demonstrate susceptibility to inhibition of signal transmission, which involves receptor of fibroblast growth factor (FGF-R) or its version, which includes determination of the status of phosphorilation of substrate 2 of FGF-R receptor (FRS-2), its version or its fragment, which contains tyrosine, in biological sample, as biomarker of such sensitivity to inhibition, where cells, demonstrating FRS-2 tyrosine phosphorilation, can be expected to demonstrate susceptibility to inhibition of signal transmission with participation of FGF-R. Method of identification of phosphorilation in FRS-2, its version or its fragment, containing tyrosine, as biomarker for cells, tissues or organs. Application of identification of phosphorilation in FRS-2, its version or its fragment, containing tyrosine, as biomarker for cells, tissues or organs, demonstrating hyperactive transmission of signal with participation of FGF-R. Application of reagent of biospecific recognition of FGF-R. Method of identifying cells, proliferation of which requires activation of FGF-R receptor.;EFFECT: application of claimed invention makes it possible to efficiently identify cells, demonstrating susceptibility to inhibition of signal transmission, involving FGF-R receptor, and cells, proliferation of which requires activation of FGF receptor, as well as perform identification of phosphorilation of phosphorilation identification in FRS-2.;10 cl, 2 tbl, 3 dwg, 1 ex