APPLICATION OF HYALURONIDASE FOR PREVENTION OR TREATMENT OF ARTERIAL HYPERTENSION OR HEART FAILURE

摘要

1. A method for the prevention and / or treatment of arterial hypertension or heart failure, comprising administering to the patient a therapeutically effective dose of hyaluronidase. ! 2. The method according to claim 1, characterized in that said arterial hypertension is selected from the group consisting of endocrine hypertension, essential hypertension, arteriosclerotic hypertension, cardiovascular hypertension, renal hypertension, labile hypertension, neurogenic hypertension, paroxysmal hypertension, paroxysmal hypertension, hypertension and secondary hypertension. ! 3. The method according to claim 1, characterized in that the patient is a human or animal. ! 4. The method according to claim 1, characterized in that the hyaluronidase should be administered via the gastrointestinal tract or parenterally. ! 5. The method according to claim 1, characterized in that at least 3,000 IU of hyaluronidase should be administered per day. ! 6. The method according to claim 1, characterized in that the hyaluronidase should be administered from 1 to 7 days per week. ! 7. The method according to claim 1, characterized in that the hyaluronidase should be administered for at least 2 weeks. ! 8. The method according to claim 1, characterized in that the dose of hyaluronidase should be increased over time, preferably until a horizontal portion is reached on the dosing time curve. ! 9. A composition containing hyaluronidase and at least one additional antihypertensive agent. ! 10. The composition according to claim 9, characterized in that the at least one additional antihypertensive agent is selected from the group comprising: diuretic, alpha-adrenergic receptor inhibitor, beta-adrenergic receptor inhibitor, inhibitor