SOVIALEM ALBUMIN MODIFICATION AS METHOD FOR STABILITY ENHANCEMENT FOR PREPARING PHARMACEUTICAL BIOLOGICAL PREPARATION OF ALBIMUN IN COMPLEX WITH GENTAMYCIN OR STIMADEN

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to medicine and concerns a method for albumin stabilisation for preparing based pharmaceutical biological preparations with additional antibiotic (gentamycin) or immunomodulating (stimadene) with mechanisms of action by sovialem protein modification.;EFFECT: invention provides higher stability of copolymer modified forms of albumin to physical (60°C, 10 hours) and chemical (gentamycin, stimadene) actions with an evident protein- denaturing effect.;2 cl, 1 ex, 1 dwg, 5 tbl