An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase

摘要

#$%^&*AU2017265180B220190801.pdf#####l:darInterw ovnNRPortblDCCDAR16058482 l.docx-23 112017 ABSTRACT The hemitartrate salt of a compound represented by the following structural formula: N O H 0 (I) (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.