Use of an agent increasing expression of nicotinic acetylcholine receptor of skin cells, as an active ingredient for preparing a cosmetic composition for improving and/or repairing the skin barrier function

摘要

Use of at least one agent increasing expression of nicotinic acetylcholine receptor of skin cells, as an active ingredient for preparing a cosmetic composition for improving and/or repairing the skin barrier function, is claimed. Independent claims are included for: (1) a cosmetic active ingredient comprising the agent composed of at least one extract of Oryza sativaand/or at least an extract of Medicago sativa; (2) a method for obtaining a cosmetic active ingredient, comprising: obtaining an active ingredient from Medicago sativa; obtaining an active ingredient from Oryza sativa; mixing at least 20% of the active ingredient from Oryza sativaand at least 50% of the active ingredient from Medicago sativa; and filtering and sterilizing the product; and (3) cosmetic composition comprising the cosmetic active ingredient (0.001-20 wt.%) increasing expression of nicotinic acetylcholine receptor of skin cells. ACTIVITY : Dermatological. MECHANISM OF ACTION : Nicotinic acetylcholine receptor stimulator. The ability of the composition (1%) (comprising cosmetic agent derived from Oryza sativaand Medicago sativa(4%)) to stimulate nicotinic acetylcholine receptor was tested in normal human keratinocytes. The result showed that the percentage expression of nicotinic acetylcholine receptor was 156.