BIOMARKER FOR COGNITIVE FUNCTION DISORDER DISEASE AND METHOD FOR DETECTING COGNITIVE FUNCTION DISORDER DISEASE BY USING BIOMARKER

摘要

PROBLEM TO BE SOLVED: To provide a method for detecting cognitive function disorder diseases including slight cognitive disorder and Alzheimer's disease by using a protein whose existing amounts are different from each other in a non-cognitive function disorder subject and a cognitive function disorder disease patient and a partial peptide of the protein, and to provide a biomarker composed of the protein and the partial peptide to detect the cognitive function disorder diseases including the light cognitive disorder and the Alzheimer's disease.;SOLUTION: The biomarker is composed of at least one protein or a peptide fragment generated from the protein and including five or more amino acid residues which are selected from proteins of array numbers 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25 and amino acid sequences expressed by 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 27 to be the array numbers of partial peptides of these proteins to diagnose the cognitive function disorder diseases, and a diagnostic method uses the biomarker.;COPYRIGHT: (C)2012,JPO&INPIT