NEW INDAZOLE DERIVATIVE OR SALT THEREOF AND PRODUCTION INTERMEDIATE THEREOF, AND PROPHYLACTIC OR THERAPEUTIC AGENT OF CHORIORETINAL DENATURATION DISEASE BY USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a prophylactic or therapeutic agent of chorioretinal denaturation diseases without substantially accompanying neovascularization, e.g. atrophic age-related macular degeneration, retinitis pigmentosa, gyrate atrophy of the choroid and retina, and further chorioretinal disorders associated with the above diseases.SOLUTION: This compound expressed by formula (1) or its pharmaceutically acceptable salt has an inhibitory effect toward photo receptor cell death in a mouse light disorder model. Therefore, it is useful as the prophylactic or therapeutic agent of chorioretinal denaturation diseases without substantially accompanying neovascularization, eg. atrophic age-related macular degeneration, retinitis pigmentosa, gyrate atrophy of the choroid and retina and further chorioretinal disorders associated with the diseases.