The normal prion protein (PrP-sen) resolution the biological sample which is doubted that pulling diagnostic manner null of the subacute transmission Characteristic

摘要

(57) this [summary] The present invention relates to a method for diagnosing subacute transmissible spongiform encephalopathy, which is caused by a non-normal transfer factor strain. Even in such strains which (1) and treated the sample with proteinase K at least, those that break down completely PrP sense in the state that can be used, the method, the octapeptide motif repetition of all or part of the PrPres It is to detect the presence of potential octapeptide motif repeats complex - Save, can be contacted with a ligand capable of specifically identifying the octapeptide motif repeats, the samples were (2) processing, (3) ligands. In addition, the present invention relates to distinguish diagnostic methods.