The external use medicine and the production manner which contain the fat acid chloride and the benzoin acid chloride of the basic medicinal effect component

摘要

The external use medicine prescription which is superior in the new percutaneous absorption regarding the basic medicinal effect component was required.The basic medicinal effect component and the organicity Acid (especially fatty acid) as an appropriate combination, lipophilicity of the medicinal effect component and the organicity Acid (logP value) the fact that it contributes to percutaneous absorption largely was discovered. Namely, if lipophilicity of the basic medicinal effect component is the chemical compound of the range of 0.5 - 5, lipophilicity of fatty acid using the chemical compound of the range of the 1 - 4, when the salt is made to form, the fact that you can obtain the percutaneous absorption which is superior was discovered. Making use of these results, it reached the point where it can offer the new external use medicine where percutaneous absorption is superior.