首页> 外国专利> Babesia microti genomic clones containing novel antigens useful in the diagnosis of Babesios

Babesia microti genomic clones containing novel antigens useful in the diagnosis of Babesios

机译：包含新型抗原的小巴贝氏菌基因组克隆，可用于诊断巴贝西奥斯

展开▼

页面导航

摘要

著录项

相似文献

摘要

Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a diagnostic assay that is sensitive, rapid and accurate using patient's sera. Also disclosed is an IgG and IgM ELISA using two novel recombinant antigens in the diagnosis of Babesia infection. 展开▼

机译：公开了小巴贝氏菌中新抗原的克隆和表达。重组多肽是高度免疫原性的。本发明的多肽提供了使用患者血清敏感，快速和准确的诊断测定的基础。还公开了使用两种新型重组抗原的IgG和IgM ELISA诊断 Babesia 感染的方法。 展开▼

著录项

公开/公告号US8178310B2

专利类型

公开/公告日2012-05-15

原文格式PDF

申请/专利权人 JOHN G. HOEY;HANNAH VENIT;MARTIN E. ADELSON;ELI MORDECHAI;FERNANDO VALOIS-CRUZ;
展开▼

申请/专利号US20090386097

发明设计人 MARTIN E. ADELSON;FERNANDO VALOIS-CRUZ;ELI MORDECHAI;HANNAH VENIT;JOHN G. HOEY;
展开▼

申请日2009-04-14

分类号G01N33/569;C07H21/04;C07K14/00;C12P21/06;

国家 US

入库时间 2022-08-21 17:29:35

相似文献

专利

外文文献

中文文献

1. 用于诊断人类和动物中活性田鼠巴贝虫和邓肯巴贝虫感染的新型分泌抗原 [P] . 中国专利： CN114072419A . 2022-02-18

2. 吉氏巴贝西虫重组抗原及其诊断试剂盒和应用 [P] . 中国专利： CN102558332B . 2014.07.02

3. Babesia microti genomic clones containing novel antigens useful in the diagnosis of babesios [P] . 美国专利： US2011306062A1 . 2011-12-15

机译：含有新型抗原的巴氏杆菌微量基因组克隆，可用于诊断巴贝杆菌

4. Babesia microti genomic clones containing novel antigens useful in the diagnosis of babesiosis [P] . 美国专利： US8388981B2 . 2013-03-05

机译：含有新型抗原的小巴贝氏菌基因组克隆，可用于诊断巴贝斯病

5. BABESIA MICROTI GENOMIC CLONES CONTAINING NOVEL ANTIGENS USEFUL IN THE DIAGNOSIS OF BABESIOSIS [P] . 美国专利： US2013177941A1 . 2013-07-11

机译：含有新型抗原的巴贝斯菌基因组在巴贝斯虫病诊断中的应用

1. Study on the production of IL-12, IL-10 in early stage after infection with Babesia microti and Babesia rodhaini in mice [J] . LIU Yun, Hachikuchi Rie, Kenichiro Ono 东北农业大学学报（英文版） . 2007,第001期

2. Antigen Gene Cloning and Expression of HIV-1 for AIDS Vaccine Design Ⅲ. HIV-1 Antigen Gene Cloning, in Vitro Expression and Antibody Induction [J] . ZENG Qingping(曾庆平), FENG Liling(冯丽玲), YANG Ruiyi(杨瑞仪), 中华性传播感染杂志（英文版） . 2002,第003期

3. Patent Issued for Babesia Microti Genomic Clones Containing Novel Antigens Useful in the Diagnosis of Babesiosis [J] . Journal of Engineering . 2013,第12期

4. Analysis of antigen‐antibody cross‐reactivity among lineages and sublineages of Babesia microti Babesia microti parasites using human babesiosis specimens [J] . Sayama Yusuke, Zamoto‐Niikura Aya, Matsumoto Chieko, Transfusion: The Journal of the American Association of Blood Banks . 2018,第5期

5. Analysis of antigen‐antibody cross‐reactivity among lineages and sublineages of Babesia microti Babesia microti parasites using human babesiosis specimens [J] . Sayama Yusuke, Zamoto‐Niikura Aya, Matsumoto Chieko, Transfusion: The Journal of the American Association of Blood Banks . 2018,第5期

6. Clonal Rearrangements of Antigen Receptor Genes in the Diagnosis of Lymphoid Neoplasia [C] . William Vernau Annual Meeting of the American Society for Veterinary Clinical Pathology . 2004

7. Molecular cloning, characterization, and immunogenicity of a species-specific Babesia microti antigen. [D] . Tetzlaff, Christine Lynn. 1988

8. Serological Expression Cloning of Novel Immunoreactive Antigens of Babesia microti [O] . Michael J. Lodes, Raymond L. Houghton, Elizabeth S. Bruinsma, 2000

9. Identification, Cloning and Characterization of BmP41, a Common Antigenic Protein of Babesia microti [O] . MASATANI, Tatsunori, OOKA, Hideo, TERKAWI, Mohamad A., 2013

10. Cloning and Expression of Genes for Dengue Virus Type-2 Encoded-Antigens forRapid Diagnosis and Vaccine Development [R] . Padmanabhan, R. K. 1991

1. 鼠感染Babesia microti和Babesia rodhaini后早期IL-12、IL-10诱生的研究 [J] . 刘云 ,小野宪一郎 . 免疫学杂志 . 2007,第1期

2. 田鼠巴贝西虫Babesia microti截短型分泌抗原的重组表达及其在诊断上的应用 [J] . 黄艳丽 ,曹杰 ,蔺智兵 . 寄生虫与医学昆虫学报 . 2012,第004期

3. hu-RBC-SCID小鼠模型的建立及野鼠Babesia microti样原虫感染人红细胞的研究 [J] . 魏强 ,迁正义 ,石原智明 . 中国比较医学杂志 . 2004,第004期

4. 贝氏柯克斯体抗原诱导人树突状细胞活化的研究 [C] . 王颖 ,吴德平 ,王锡乐 . 2010中国人兽共患病学术交流会 . 2010

5. 贝氏柯克斯体抗原诱导人树突状细胞活化的研究 [A] . 王颖 . 2010