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Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase
Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase
This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs and more specifically SEQ ID NOS: 1-4. This invention also relates to antibodies specific for the peptides and to immune complexes of these antibodies with the peptides. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.
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机译:本发明涉及外消旋体的鉴定和表征以及这些外消旋体的蛋白质标记的定义。更具体地,本发明涉及编码由蛋白质签名的特征性基序组成的肽的核酸分子的鉴定,并且涉及由这些基序且更具体地为SEQ ID NOS:1-4组成的肽。本发明还涉及对肽具有特异性的抗体,以及这些抗体与肽的免疫复合物。此外,本发明涉及使用本发明的核酸分子检测消旋体的方法和试剂盒,以及由基序和针对这些肽的抗体组成的肽。
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