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Method for obtaining a 2- 18F fluor-2-deoxy-D-glucose 18F-FDG-solution

机译:2- 18 F氟-2-脱氧-D-葡萄糖 18 F-FDG溶液的制备方法

摘要

The invention relates to a method for improving one or more physical/chemical characteristics, like reduced radiolysis of and the ability to autoclave, a 18F-fluor-deoxy-glucose (18F-FDG)-solution, which method comprises the steps of a) provision of a 18F-fluor-deoxy-glucose (18F-FDG)-solution, and b) addition of at least one buffer based on a weak acid to the 18F-fluor-deoxy-glucose (18F-FDG)-solution. The invention also relates to a method for preparing a sterile 18F-fluor-deoxy-glucose (18F-FDG)-solution by autoclaving said 18F-fluor-deoxy-glucose (FDG)-solution.
机译:本发明涉及一种用于改善一种或多种物理/化学特性的方法,例如降低18F-氟-脱氧-葡萄糖(18F-FDG)溶液的辐射分解和对其进行高压灭菌的能力,该方法包括以下步骤:提供18 F-氟-脱氧葡萄糖(18F-FDG)溶液,以及b)向18F-氟-脱氧葡萄糖(18F-FDG)溶液中添加至少一种基于弱酸的缓冲剂。本发明还涉及通过高压灭菌所述18F-氟-脱氧-葡萄糖(FDG)溶液来制备无菌18F-氟-脱氧-葡萄糖(18F-FDG)溶液的方法。

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