COMPOSITION COMPRISING A PVL ANTIGEN OF STAPHYLOCOCCUS AUREUS FOR THE TREATMENT OF STAPHYLOCOCCUS AUREUS INFECTION

摘要

The present invention relates to compositions and methods for treating Staphylococcus aureus (S. aureus) infections. In particular, the present invention provides vaccines comprising a Panton- Valentine Leukocidin (PVL) antigen, antibodies which bind a PVL antigen and compositions containing the same, methods of making such compositions and methods for treating S. aureus infections, including those that are community acquired methicillin-resistant infections. The present invention also provides PVL antibodies, including PVL antibodies specific for a single PVL subunit, and PVL antigens, including conjugated and mutated PVL antigens.