Hydrochloride Salt of (1S, 2S, 4R) - 4 - (4 - (1S) - 2,3 dihydro - 1 - 1 - ilamino inden - - 7h pyrrolo 2,3-d pyrimidine 7 - il} - 2 - hidroxiciclopentil) metilsulfamato

摘要

Refers to a hydrochloride Salt of (1S, 2S, 4R) - 4 - (4 - [(1S) - 2,3 dihydro - 1 - 1 - ilamino inden -] - 7h pyrrolo [2,3-d] pyrimidine 7 - il} - 2 - hidroxiciclopentil) which includes: (metilsulfamato 1) to a form that is characterized by a pattern of x-ray Powder diffraction (XRPD) with peaks at Angles 2theta: 9.6u00ba, 13.6u00ba and 19.1u00ba or 9.6u00ba, 13.6u00ba, 14.5u00ba, 19.1u00ba and 23.7th; (b) a form 2 is characterized by a XRPD with Peaks in 2theta Angles: 8.7u00ba, 18.2u00ba and 23.8u00ba or 8.7u00ba, 18.2u00ba, 19.4u00ba, 23.8u00ba, 24.3u00ba and 27.5u00ba; (c) a third way that is characterized by a XRPD with Peaks in 2theta Angles: 10.9u00ba, 14.6u00ba, 19.5u00ba and 24.0u00ba or 10.9u00ba, 14.6u00ba, 16.9u00ba, 19.5u00ba, 24.0u00ba and 25.9; (d) a form 3B that is characterized by a XRPD with Peaks in 2theta Angles: 10.8u00ba, 16.9u00ba, 23.7u00ba and 24.0u00ba or 10.8u00ba, 14.5u00ba, 16.9u00ba, 19.3u00ba, 21.2u00ba, 23.7u00ba, 24.0u00ba and 28.8u00ba; (e) a 3C which are characterized by a XRPD with Peaks in 2theta Angles 11.0u00ba, 12.2u00ba: And 24.4u00ba; 11.0u00ba, 12.2u00ba, 14.9u00ba, 19.8u00ba, 24.0u00ba and 24.4th; (f) a form 5 that is characterized by a XRPD with Peaks in 2theta Angles: 16.7u00ba and 22.9u00ba or 16.7u00ba, 17.2u00ba, 18.1u00ba and 22.9u00ba; (g) a 7 that is characterized by a XRPD with Peaks in 2theta Angles: 15.4u00ba, 17.3u00ba, 19.6u00ba and 22.5u00ba or 10.0u00ba, 15.4u00ba, 16.6u00ba, 17.3u00ba, 18.0u00ba, 18.3u00ba, 19.6u00ba, 22.0u00ba and 22.5u00ba.This Compound is an inhibitor of E1 Activating Enzyme useful in Cancer Treatment