2 - amino - 5.5 - difluor - 5.6 - dihydro - 4 - oxazines as bace inhibitors and / or bace 1 2

摘要

Refers to a compound of formula (i) wherein: R1 is aryl, heteroaryl, Lower alkyl, cycloalkyl, among others; R2 is H, alkyl and Halogen less; R3 is lower alkyl; R4 and R5 are independently H and Lower alkyl; n is 0, 1, or 2.Preferred compounds are: [3 - ((R) - 2 - amino - 4 - methyl - 5.5 - difluor 5,6 dihydro - 4H - [1,3] - oxazin - 4-yl) - 4 - Fluorine phenyl amide acid] - 5 - Chloro - pyridine - 2 - [3 - carboxylic acid; ((R) - 2 - amino - 4 - methyl - 5.5 - difluor 5,6 dihydro - 4H - [1,3] - oxazin - 4-yl) - 4 - Fluorine phenyl amide acid] - 5 - fluoro pyridine carboxylic acid - 2 - [3 - ((R; 5.5) - 2 - amino - 4 - methyl - - difluor 5,6 dihydro - 4H - [1,Oxazin] - 3 - 4 - 4 - fluoro - il) - phenyl] - 3 - Chloro - amide acid - 2 - pyridine carboxylic acid; among others. It also relates to a Pharmaceutical Composition and a process for obtaining. This Compound is an inhibitor of BACE1 and BACE2, being useful in the treatment of Alzheimer's disease and Metabolic Disorders