Lipopeptides novel immunogenic epitopes comprising helper T cells and B cells.

摘要

Lipopeptide comprising a polypeptide conjugated to one or more lipid moieties wherein: (i) said polypeptide comprises an amino acid sequence comprising: (a) the amino acid sequence of an epitope of T-helper (Th) and the sequence amino acids of a B cell epitope, wherein said amino acid sequences are different; and (b) one or more internal lysine residues or residues internal lysine analog for covalent attachment of each of said lipid moieties via the epsilon-amino or terminal group side chain of said lysine or lysine analog ; and (ii) each of said one or more lipid moieties is covalently attached to an epsilon-amino group of said one or more internal lysine residues or to a terminal group of said one or more residues internal lysine analog side chain; wherein the internal lysine residue or the residue of internal lysine analog to which is attached a lipid moiety is positioned (a) between the Th epitope and the B epitope, or (b) cells within the Th epitope.