SPIRIT COMPOUNDS AND METHODS OF USE.

摘要

A spiro compound of Formula IP Formula I In which P a is 1; b and c are each independently 1; P a) When X and Y are selected from: P (i) X is combined with Y to be an oxygen or methylene, (ii) X is hydrogen, Y is hydrogen, (iii) X is hydrogen, Y is hydroxy or its optical isomer; P R '' and R "do not occur; These groups being selected from ketone, methylene, hydroxy or their optical isomer; P b) When X and Y are chosen from: P (iv) X is hydrogen, Y is O, S or its optical isomer position, (v) X and Y are both O or S, (vi) X is O and Y is S; P R '' and R "are each independently selected from halogen lower alkyl, lower alkyl , lower alkoxy, hydroxy, lower hydroxyalkyl; or R '', R ", X, Y and the spiro carbon combine to form a ring of 5 to 7 atoms that can be substituted or not independently by up to three substituents selected from lower alkyl, aryl or heterocyclic; R is selected from : Ra is lower alkylene, Rb is halogen or hydroxy; W is chosen from O, S, -NRc or -CHRc; G is chosen from N, -C-CN or -CRc; Z is chosen from O, S, -NRd or -CHRd; Rc is chosen from H, lower alkyl; Rd is chosen from H, lower alkyl, amino or alkylamino; R1, R3, and R4 are each independently chosen from H, halogen, lower alkyl 5 halogen, lower alkyl , lower alkoxy, lower alkoxyalkoxy, lower alkenyl, or lower alkynyl; R2 is selected from H, halogen, lower halogen alkyl or lower alkyl; or a pharmaceutically acceptable salt thereof.