METHOD FOR DETECTING AND PURIFYING TCD8+ LYMPHOCYTE POPULATIONS, SPECIFIC OF PEPTIDES PRESENT IN THE CONTEXT OF HLA

摘要

The invention relates to multimers produced from recombinant proteins analogous to MHC class I, characterized in that the proteins comprise at least one alteration in the zone of interaction of a heavy chain with the CD8 co-receptor of T lymphocytes. leading to a reduction, even the suppression of the affinity of the interaction between the heavy chain and CD8. Applications of these complexed multimers to antigenic peptides for diagnostic and therapeutic purposes.