COMPOUNDS AND METHOD OF TREATMENT HAVING AGONIST-LIKE ACTIVITY SELECTIVE AT ALPHA 2B OR 2B/2C ADRENERGIC RECEPTORS

摘要

A compound having a structure selected from the group consisting of: in whicheach x is independently (1) or (2); Y is selected from the group consisting ofO;S;N;-(C(R7)z)s-where each R7 IS independently as previously defined fir R1,each z is independently 1-2, and s is 1-3;CH=; -CH=CH ;or Y1CH2_where Y1 is O,N, or S; and the dotted lines are optional double bonds, with the pviso thatif the ring including Y is a cyclohexane ring or a heterocyclic 5 member ringsaid ring is not fully unsaturated, and that if Y is O,N or S, the ringincluding Y contains at least one said double bond, said compound furtherhaving selective agonist activity at the .alpha.2B or .alpha.2B/.alpha.2Cadrenergic receptor subtype(s) over the .alpha.2A adrenergic receptor subtype,and all pharmacologically acceptable salts, esters, stereoisomers and racemicmixtures thereof.