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MODULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE-MITOCHONDRIAL (PEPCK-M) EXPRESSION
MODULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE-MITOCHONDRIAL (PEPCK-M) EXPRESSION
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机译:磷酸磷酸丙酮酸羧激酶-线粒体(PEPCK-M)表达的调节
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摘要
Provided herein are methods, compounds, and compositions for reducing expression of phosphoenolpyruvate carboxykinase-mitochondrial (PEPCK-M) mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preventing or decreasing diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia, or a symptom thereof.
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