POLYAMIDE-AMINE DENDRIMER OR DERIVATIVE THEREOF-MATH1 GENE NANO PARTICLE AND USE THEREOF IN TREATMENT OF HEARING LOSS

摘要

Provided are polyamide-amine (PAMAM) dendrimer or derivative thereof-Math1 gene nano particles, a preparation method therefor and a use thereof in treatment of hearing loss. The gene nano particles are prepared by subjecting PAMAM dendrimer or a derivative thereof, for example, PAMAM or a PAMAM-cyclodextrin complex activated through thermal treatment, and a Math1 gene containing plasmid to complex coacervation, and the gene nano particles are useful in treatment of sensorineural hearing loss caused by hair cell loss.