A DRUG CARRIER FOR TUMOR-TARGETED THERAPY, ITS PREPARATION METHOD AND ITS USE

摘要

A drug carrier with the capability of systemic administration through intravenous injection, its preparation methods and its use for tumor gene therapy. The carrier is composed of l,2-bis(olcoyloxy)-3-(trimethylammonio)-propane (DO TAP) or its analogue and lecithin or its derivative in molar ratio of 20:(7-13), wherein the DOTAP analogue is selected from DOTMA, DDAB or methyl sulfate DOTAP, and the lecithin derivative is selected from DOPC, DOPS or DOPE. The carrier of the present invention can form stable complex with bioactive materials and deliver these bioactive materials to the targeted cells cultured in vitro or in vivo, wherein the bioactive materials is DNA of tumor suppressor genes or cell suicide gene and so on. The particle size of the complex is reduced to 200nm or below.